Accession Number : ADD012640

Title :   Oral Vaccine for Immunization against Enteric Disease.

Descriptive Note : Patent,

Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON DC

Personal Author(s) : Formal,Samuel B ; Baron,Louis S ; Kopecko,Dennis J

Report Date : 30 Dec 1986

Pagination or Media Count : 8

Abstract : A living, attenuated, oral vaccine system is described for the immunization against enteric disease. This oral vaccine is a genetic hybrid derivative of an attenuated galactose epimeraseless strain of S. typhi which carries at least one protective antigen other than normal somatic S. typhi antigens. The oral vaccine can provide protection against both typhoid fever and at least one other enteric disease. A bivalent oral vaccine is described wherein the non-typhoid protective antigen is the plasmid-encoded form I antigen of Shigella sonnei. A protective antigen from Shigella sonnei was transferred to a streptomycin resistant mutant of S. typhi strain Ty21a. The transconjugant S. typhi strain expressed both S. typhi and S. sonnei antigens and protected experimental animals against lethal infections with either S. typhi of S. sonnei. This strain is considered to be useful as a vaccine against typhoid fever and bacillary dysentery caused by S. sonnei. The mutated galactose epimeraseless S. typhi strain such as S. typhi Ty21a strain can be utilized as a carrier strain for other protective antigens. (Patents).

Descriptors :   *PATENTS, *SALMONELLA TYPHOSA, *ENTERIC BACTERIA, *ORAL INTAKE, *vACCINES, *SHIGELLA SONNEI, STRAINS(BIOLOGY), GALACTOSE, ANTIGENS, INFECTIOUS DISEASES, LETHALITY, BACILLARY DYSENTERY, GASTROINTESTINAL DISEASES, GENETICS, HYBRID SYSTEMS, IMMUNIZATION, ORAL INTAKE, LABORATORY ANIMALS, MUTATIONS, RESISTANCE(BIOLOGY), STREPTOMYCINS, TYPHUS, FEVERS

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE