Accession Number : ADD012741

Title :   Esters of Boron Analogues of Amino Acids.

Descriptive Note : Patent,

Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON DC

Personal Author(s) : Spielvogel,Bernard F ; McPhail,Andrew T ; Hall,Iris H

Report Date : 03 Mar 1987

Pagination or Media Count : 4

Abstract : Ester analogues of boron analogues of amino acid are disclosed. Also disclosed is a method of forming the ester analogues in high yield by condensation of the corresponding acids and alcohols with dicylohexylcarbodiimide at room temperature in dichloromethane. The disclosed compounds have shown interesting biological activities, in particular, hypolipidemic activity as well as significant antitumor and antiarthritic activities.

Descriptors :   *PATENTS, *BORON, *SYNTHESIS(CHEMISTRY), *CHEMOTHERAPEUTIC AGENTS, *AMINO ACIDS, *ESTERS, ACIDS, ALCOHOLS, BIOLOGY, CHLOROMETHANES, CONDENSATION, HIGH RATE, ROOM TEMPERATURE, IMIDES, LIPIDS, ARTHRITIS, CHOLESTEROL, GLYCERIDES

Subject Categories : Biochemistry
      Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE