Accession Number : ADD013325

Title :   Conversion of Prostaglandin Analogs into a Bicarbonate Insoluble Oligomeric Mixture.

Descriptive Note : Patent, Filed 6 May 83, patented 5 May 87,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Nelson, George L

Report Date : 05 May 1987

Pagination or Media Count : 4

Abstract : A method for oligomerization of a group of prostaglandin analogs such as the Ethyl Analog 3-(trans-3-keto-1-pentenyl1)-2ethyl-2-cyclopentenone into a biologically active exhibiting protection of oxidative phosphorylation of degenerated mitochondria and sodium bicarbonate insoluble oligomeric mixtures is described. The Ethyl Analog is treated with ethanolic potassium hydroxide solution in an oxygen-free atmosphere at moderate conditions of temperature, time and concentration.

Descriptors :   *PATENTS, *POLYMERIZATION, BICARBONATES, CONVERSION, ETHANOLS, ETHYL RADICALS, HYDROXIDES, MIXTURES, OXIDATION, PHOSPHORYLATION, POTASSIUM, PROSTAGLANDIN, SODIUM COMPOUNDS, SOLUTIONS(MIXTURES), CHEMICAL ANALOGS, CHEMICAL DERIVATIVES

Subject Categories : Polymer Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE