Accession Number : ADD013456
Title : Process for the Preparation of Detoxified Polysaccharide-Outer Membrane Protein Complexes, and Their Use as Antibacterial Vaccines.
Descriptive Note : Patent, Filed 17 Sep 85, patented 17 Nov 87,
Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON DC
Personal Author(s) : Zollinger, Wendell D ; Boslego, John ; Moran, Ellen ; Brandt, Brenda ; Collins, Hugh
Report Date : 17 Nov 1987
Pagination or Media Count : 19
Abstract : This invention relates to a novel means for affording treatment and control of infections in animals, including human beings and other mammalian species, which may becaused by gram-negative bacteria. It is based upon the use or administration of immunogenically effective amounts of a detoxified polysaccharide-outer membrane protein complex against infection by the same bacteria from which it has been derived. The term polysaccharide as used herein includes lipopolysaccharides and capsular polysaccharides.
Descriptors : *GRAM NEGATIVE BACTERIA, *VACCINES, *PATENTS, *PROTEINS, ANIMALS, BACTERIA, CONTROL, GERMICIDES, HUMANS, INFECTIOUS DISEASES, LIPOPOLYSACCHARIDES, MAMMALS, POLYSACCHARIDES, DETOXIFICATION, MEMBRANES(BIOLOGY)
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE