Accession Number : ADD013456

Title :   Process for the Preparation of Detoxified Polysaccharide-Outer Membrane Protein Complexes, and Their Use as Antibacterial Vaccines.

Descriptive Note : Patent, Filed 17 Sep 85, patented 17 Nov 87,

Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON DC

Personal Author(s) : Zollinger, Wendell D ; Boslego, John ; Moran, Ellen ; Brandt, Brenda ; Collins, Hugh

Report Date : 17 Nov 1987

Pagination or Media Count : 19

Abstract : This invention relates to a novel means for affording treatment and control of infections in animals, including human beings and other mammalian species, which may becaused by gram-negative bacteria. It is based upon the use or administration of immunogenically effective amounts of a detoxified polysaccharide-outer membrane protein complex against infection by the same bacteria from which it has been derived. The term polysaccharide as used herein includes lipopolysaccharides and capsular polysaccharides.

Descriptors :   *GRAM NEGATIVE BACTERIA, *VACCINES, *PATENTS, *PROTEINS, ANIMALS, BACTERIA, CONTROL, GERMICIDES, HUMANS, INFECTIOUS DISEASES, LIPOPOLYSACCHARIDES, MAMMALS, POLYSACCHARIDES, DETOXIFICATION, MEMBRANES(BIOLOGY)

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE