Accession Number : ADD013479

Title :   Conversion of Prostaglandin Analogs Into a Bicarbonate Soluble Oligomeric Mixture.

Descriptive Note : Patent, Filed 6 May 83, patented 26 May 87,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Nelson, George L

Report Date : 26 May 1987

Pagination or Media Count : 8

Abstract : This invention is related to prostaglandin analogs and method of preparation thereof, as precursors for the synthesis of oligomeric mixtures showing biological activity with regard to restoration of oxidative phosphorylation in the degenerated mitochondria and more particularly to oligomerization of the Ethyl Analog having low molecular weights which give rise to oligomeric mixture having various components thereof biologically active in vitro. A method for oligomerization of a group of prostaglandin analogs such as the Ethyl Analog 3-(trans-3-keto-1-pentenly)-2-ethyl-2-cyclopentenone into a biologically active exhibiting protection of oxidative phosphorylation of degenerated mitochondria and sodium bicarbonate soluble oligomeric mixtures is described. The Ethyl Analog is treated with ethanolic potassium hydroxide solution with exposure to atmospheric oxygen at moderate conditions of temperature, time and concentration. Keywords: Patents.

Descriptors :   *PATENTS, *POLYMERIZATION, *PROSTAGLANDIN, ANALOG SYSTEMS, ANALOGS, BICARBONATES, BIOLOGY, CONVERSION, ETHANOLS, ETHYL RADICALS, HYDROXIDES, IN VITRO ANALYSIS, MIXTURES, MOLECULAR WEIGHT, OXIDATION, PHOSPHORYLATION, POTASSIUM, SOLUBILITY, SOLUTIONS(MIXTURES), TEMPERATURE, MITOCHONDRIA, SYNTHESIS(CHEMISTRY)

Subject Categories : Organic Chemistry
      Polymer Chemistry
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE