Accession Number : ADD013956

Title :   Method for Inducing Protection in Animal Against Cyanide Poisoning Using 8-Aminoquinolines.

Descriptive Note : Patent, Filed 30 Jun 86, patented 28 Feb 89,

Corporate Author : DEPARTMENT OF THE ARMY WASHINGTON DC

Personal Author(s) : Canfield, Graig J ; Heiffer, Melvin H ; Korte, Don W , Jr

Report Date : 28 Feb 1989

Pagination or Media Count : 6

Abstract : This invention relates to novel means for inducing the production of blood methemoglobin in animals, at sufficient levels to afford post-or pretreatment of said animals against poisoning resulting from exposure to toxic levels of cyanide. It is based upon the use or administration of therapeutically effective amount of certain 8-aminoquinoline compositions which are administered orally. The present invention avoids many problems associated with previously known treatments by orally administering a compound to induce constant, ongoing levels of methemoglobin sufficient to provide protection to animals, against exposure to toxic levels of cyanide. For persons likely to be exposed to cyanide, this is 60 a preventive measure rather than a post-exposure method treatment. Keywords: Patents, Antidotes, Preventive medicine. (KT/AW)

Descriptors :   *ANTIDOTES, *METHEMOGLOBIN, *TOXINS AND ANTITOXINS, ANIMALS, BLOOD, CYANIDES, EXPOSURE(PHYSIOLOGY), LEVEL(QUANTITY), PATENTS, POISONING, PREVENTION, PREVENTIVE MEDICINE, PRODUCTION, PROTECTION, TOXICITY

Subject Categories : Pharmacology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE