Accession Number : ADD014076

Title :   Method for Immunosuppression.

Descriptive Note : Patent, Filed 19 Sep 84, patented 23 Aug 88,

Corporate Author : DEPARTMENT OF THE AIR FORCE WASHINGTON DC

Personal Author(s) : Kiel, Jonathan L

Report Date : 23 Aug 1988

Pagination or Media Count : 6

Abstract : This invention relates to biochemistry and more particularly to an enzymatic preparation for the control of tumor growth and immune diseases, and a process of administering said preparation to mammals. This invention further relates to a process for suppressing the immune diseases, and a process of administering said preparation to mammals. This invention further relates to a process for suppressing the immune system of animals wherein an effective amount of 3-aminotyrosine is administered to animals for suppressing the endogenous immune system thereof. We have discovered that several peroxidases, when used in combination with a hydrogen peroxidases, and /or superoxide generating system, possess a potent cytotoxic activity when administered to tumor-bearing animals and cytolytic activity toward prokaryotic and eukaryotic cells. We further discovered that this cytotoxic activity appears to the exclusively directed toward the neoplastic tissues. In order to obtain the tumoricidal activity, it is necessary that the two enzymes be kept in close proximity to each other and that the enzymes be stabilized such as to significantly increase their in vivo half-life. Both These requirements can be met by immobilizing the enzymes, either separately or in combination, onto an insoluble support. One or more injections of the immobilized enzyme conjugate described above into tumor-bearing animals results in a partial or total regression of the tumor tissue. It is preferable that the material be injected into the tumor or proximal to the tumor; however. Keywords: Patents. (aw)

Descriptors :   *PATENTS, *ENZYMES, *IMMUNOLOGY, *NEOPLASMS, *IMMUNOSUPPRESSION, TYROSINE, PEROXIDASES, SUPEROXIDES, INJECTIONS(MEDICINE)

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE