Accession Number : ADD015211

Title :   Tin-124 Labelled Tetra-n-butyltin and Tri-n-butyltin Bromide.

Descriptive Note : Patent, Filed 29 Sep 89, patented 22 Oct 91,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Dooley, Carol A ; Testa, John P , Jr

Report Date : 22 Oct 1991

Pagination or Media Count : 7

Abstract : This patent discloses the stable isotope-labelled tetra-n-butyl(124) tin that was synthesized by the reaction of n-butylmagnesium bromide with 124SnCl4 and that tri-n-butyltin bromide was synthesized by bromine cleavage of the tetraalkyltin. The tri-n-butyl(124)tin compound labelled with the stable isotope 124SN is useable in environmental, chemical and biological applications to determine the fate, uptake and metabolism of tributyltin compounds. This determination is made by tracing the chemical, biological and physical processes by using gas chromatography(GC) and electron impact low resolution mass spectrometry(MS). The simplified spectra of the isotopically enriched compounds leads to a twofold increase in detection sensitivity by the GC and MS techniques.

Descriptors :   *PATENTS, *ORGANOMETALLIC COMPOUNDS, *BUTYL RADICALS, *TIN COMPOUNDS, *ISOTOPES, BIOLOGY, BROMINE, BUTANES, CHEMICALS, CLEAVAGE, DETECTION, ENRICHMENT, METABOLISM, ORGANOMETALLIC COMPOUNDS, PATENTS, SENSITIVITY, SIMPLIFICATION, SPECTRA, SYNTHESIS, TIN COMPOUNDS

Subject Categories : Organic Chemistry
      Isotopes
      Radiation and Nuclear Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE