Accession Number : ADD015255

Title :   Protective Four Amino Acid Epitope Against Plasmodium vivax Malaria.

Descriptive Note : Patent, Filed 6 Nov 90, patented 10 Mar 92,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Hoffman, Stephen L ; Charoenvit, Yupin ; Jones, Trevor T

Report Date : 10 Mar 1992

Pagination or Media Count : 6

Abstract : A synthetic peptide of the human malaria Plasmodium vivax, containing at least one repeat of a synthetic peptide having the amino acid sequence Ala-Gly-Asp-Arg (AGDR) which is a protective epitope found on the circumsporozoite (CS) protein of the sporozoites of the human malaria Plasmodium vivax. When a monoclonal antibody specific for this four amino acid sequence binds to the CS protein of the P. vivax sporozoite in vivo, infection is prevented. Also described are pharmaceutical formulations of these peptides.

Descriptors :   *AMINO ACIDS, *MALARIA, *PROTEINS, ACIDS, ANTIBODIES, FORMULATIONS, HUMANS, MONOCLONAL ANTIBODIES, PEPTIDES, PLASMODIUM, PLASMODIUM VIVAX, SEQUENCES, SPOROZOITES, PATENTS

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE