Accession Number : ADD015304

Title :   Immuno-Dye Reagent and Assay for Detection of Endotoxin.

Descriptive Note : Patent, Filed 29 Sep 89, patented 3 Mar 92,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Williams, Taffy J ; Lee, Che-Hung ; Johnson, Akindele O

Report Date : 03 Mar 1992

Pagination or Media Count : 4

Abstract : A novel immuno-dye reagent capable of detecting the presence of endotoxin in samples has been developed. The immuno-dye reagent comprises a solution of new methylene blue and an anti-endotoxin monoclonal antibody specific to a selected endotoxin. The immuno-dye reagent can be used in an assay to detect endotoxin by reacting the immuno-dye reagent with an endotoxin suspect pH adjusted sample, under hydrophobic conditions. The immuno-dye reagent can also be used in any application where binding of endotoxin is crucial, such as purifying endotoxin-contaminated solutions.

Descriptors :   *ENDOTOXINS, ANTIBODIES, BLUE(COLOR), DYES, METHYLENE BLUE, METHYLENES, MONOCLONAL ANTIBODIES, DETECTION, PATENTS

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE