Accession Number : ADD015304
Title : Immuno-Dye Reagent and Assay for Detection of Endotoxin.
Descriptive Note : Patent, Filed 29 Sep 89, patented 3 Mar 92,
Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC
Personal Author(s) : Williams, Taffy J ; Lee, Che-Hung ; Johnson, Akindele O
Report Date : 03 Mar 1992
Pagination or Media Count : 4
Abstract : A novel immuno-dye reagent capable of detecting the presence of endotoxin in samples has been developed. The immuno-dye reagent comprises a solution of new methylene blue and an anti-endotoxin monoclonal antibody specific to a selected endotoxin. The immuno-dye reagent can be used in an assay to detect endotoxin by reacting the immuno-dye reagent with an endotoxin suspect pH adjusted sample, under hydrophobic conditions. The immuno-dye reagent can also be used in any application where binding of endotoxin is crucial, such as purifying endotoxin-contaminated solutions.
Descriptors : *ENDOTOXINS, ANTIBODIES, BLUE(COLOR), DYES, METHYLENE BLUE, METHYLENES, MONOCLONAL ANTIBODIES, DETECTION, PATENTS
Subject Categories : Toxicology
Distribution Statement : APPROVED FOR PUBLIC RELEASE