Accession Number : ADD015749

Title :   Protective Malaria Sporozoite Surface Protein Immunogen and Gene.

Descriptive Note : Patent, Filed 10 Jan 91, patented 30 Mar 93,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Hoffman, Stephen L ; Charoenvit, Yupin ; Hedstrom, Richard ; Khusmith, Srisin ; Rogers, William O , IV

Report Date : 30 Mar 1993

Pagination or Media Count : 11

Abstract : A protein antigen (SSP2) on the surface of Plasmodium sporozoites is disclosed as a candidate immunogen for vaccination against malaria. This use of this protein, which is distinct from the extensively characterized circumsporozoite (CS) protein, will also facilitate research into host immunological responses to malaria. This antigen is detected by a monoclonal antibody (NYS4) which is specific for a 140 kilodalton (kD) protein on the sporozoite cell surface. Immunoreactive genomic clones are described which express this surface antigen gene and the primary nucleic acid sequence and the deduced amino acid sequence derived from this DNA sequence are disclosed. Unique repetitive sequences of amino acids are described which further demonstrate the distinction between SSP2 and the CS protein.

Descriptors :   *ANTIGENS, *CELLS, *CLONES, *IMMUNIZATION, *IMMUNOGENS, *MALARIA, *MONOCLONAL ANTIBODIES, *PLASMODIUM, *PROTEINS, *SPOROZOITES, *VACCINES, *BIOCHEMISTRY, *DEOXYRIBONUCLEIC ACIDS, *AMINO ACIDS, *NUCLEIC ACIDS, RESPONSE, SURFACES

Subject Categories : Pharmacology
      Microbiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE