Accession Number : ADD015824

Title :   Recombinant Leishmania Containing Genes Encoding Proteins From Infectious Disease Agents and Method of Inducting Cellular Immune Response.

Descriptive Note : Patent Application, filed 5 Apr 93,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Rogers, William O ; Hoffman, Stephen L

Report Date : 05 Apr 1993

Pagination or Media Count : 21

Abstract : This invention relates to recombinant strains of Leishmania which express foreign proteins, useful for vaccination against infectious diseases. More particularly, this invention relates to strains of Leishmania expressing the circumsporozoite protein, sporozoite surface protein 2, or other Plasmodium antigens which, when administered as vaccine components, either alone or in combination with other malarial antigens, can confer protective immunity against malaria

Descriptors :   *LEISHMANIA, *PATENT APPLICATIONS, *INFECTIOUS DISEASES, MALARIA, VACCINES, PLASMODIUM, HOSTS(BIOLOGY), INSECTS, PARASITES, SPOROZOITES, ANOPHELES, STRAINS(BIOLOGY), ANTIGENS, IMMUNITY

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE