Accession Number : ADD016130

Title :   Polynucleotide Vaccine Protective Against Malaria, Methods of Protection and Vector for Delivering Polynucleotide Vaccines. N9

Descriptive Note : Patent Application, Filed 23 Nov 93,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Sedegah, Martha ; Hedstrom, Richard ; Hoffman, Stephen

Report Date : 23 Nov 1993

Pagination or Media Count : 50

Abstract : This invention relates to polynucleotide vaccines protective against malaria, and a vector for construction of this and other polynucleotide vaccines. More particularly, this invention relates to vaccines composed of, at a minimum, nucleotides encoding one or more Plasmodium species proteins, and compositions and methods of providing protection against malaria with such a polynucleotide vaccine. Also, the invention includes a plasmid vector including a cytomegalovirus promotor for insertion of nucleotides encoding targets of protective immune responses.

Descriptors :   *PATENT APPLICATIONS, *VACCINES, *MALARIA, PLASMIDS, IMMUNITY, SPOROZOITES, INFECTIOUS DISEASES, ANTIGENS, PARASITES, STRATEGY, BIOLOGY, PEPTIDES, CHEMISTRY, IMMUNOLOGY

Subject Categories : Microbiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE