Accession Number : ADD017287

Title :   99M TC Labeled Liposomes.

Descriptive Note : Patent, Filed 30 May 90, patented 27 Oct 92,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Phillips, William T ; Klipper, Robert W ; Timmons, James H ; Rudolph, Alan S

Report Date : 27 Oct 1992

Pagination or Media Count : 13

Abstract : The invention relates to a 99m-Tc-labeled liposome encapsulated protein and to a highly efficient method of radiolabeling liposome encapsulated protein. In particular, a 99mTc carrier is used to label preformed liposome encapsulated hemoglobin. The liposome-encapsulated 99MTc labeled hemoglobin is highly stable in vitro and in vivo and is suitable for a variety of clinical uses, including biodistribution imaging studies. The invention also relates to a method of using technetium-99mTc-labeled liposome encapsulated hemoglobin to label neutrophils. A kit method which could be used for the convenient preparation of 99mTc-labeled liposome encapsulated hemoglobin for clinical use is also disclosed.

Descriptors :   *LIPOSOMES, *HEMOGLOBIN, STABILITY, PROTEINS, CLINICAL MEDICINE, EFFICIENCY, IN VITRO ANALYSIS, IMAGES, ENCAPSULATION, CYTOPLASM, IN VIVO ANALYSIS, LABELED SUBSTANCES, RADIOACTIVE ISOTOPES, KITS, POLYMORPHONUCLEAR NEUTROPHILS, BIOSTATISTICS, MATERIAL FORMING

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE