Accession Number : ADD017410

Title :   Decaying Radiolabelled Lymphocytes and Method of Using Same Background of the Invention.

Descriptive Note : Patent Application, Filed 30 Dec 94,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Chambers, George P

PDF Url : ADD017410

Report Date : 30 Dec 1994

Pagination or Media Count : 14

Abstract : Decaying radiolabelled lymphocytes and a method of using same are disclosed. A radiolabelled T-cell lymphocyte including a T-cell containing a Beta-emitting isotope which decays to an alpha-emitting isotope is provided. Alternatively, the T-cell may contain a Beta-emitting isotope which decays one of an x-ray and gamma-emitting isotope. A therapeutic radioisotope treatment method includes the steps of removing a cancerous nodule containing T-cells from a mammal, introducing into the T-cells a Beta-emitting isotope which decays to an alpha-emitting isotope and infusing the T-cells containing the Beta-emitting isotope which decays to an alpha-emitting isotope into the mammal. As an alternative, the treatment method may introduce into the T-cells a Beta-emitting isotope which decays to an x-ray or gamma-emitting isotope. Then, according to the alternative method, after the radioactive T- cells are infused into the mammal, the patient is monitored with a radiation detector to determine the location of T-cells containing the isotopes.

Descriptors :   *PATENT APPLICATIONS, *RADIOACTIVE ISOTOPES, *RADIATION EFFECTS, RADIATION, DETECTORS, MAMMALS, ISOTOPES, BACKGROUND, THERAPY, INVENTIONS

Subject Categories : Radiobiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE