Accession Number : ADD017758

Title :   Process for the Preparation of Headgroup-Modified Phospholipids using Phosphatidylhydroxyalkanols as Intermediates.

Descriptive Note : Patent, Filed 30 Jul 93, patented 15 Aug 95,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Singh, Alok

Report Date : 15 Aug 1995

Pagination or Media Count : 8

Abstract : Phospholipase D enzyme is used to mediate the synthesis of a phosphatidylhydroxyalkanol in a first step. This phosphatidylhydroxyalkanol is reacted to produce a headgroup modified phospholipid in a subsequent step. In the first step, phospholipase D enzyme extract mediates transphosphatidylation of a phospholipid with an alcohol containing at least two hydroxyl groups per molecule, producing reproducible and nearly quantitative yields of a phosphatidylhydroxyalkanol. In the subsequent step, the hydroxyl head group of the phosphatidythydroxyalkanol is further reacted with amino carboxylic, halogen or thiol containing molecules to produce a headgroup modified phospholipid. jg p.1

Descriptors :   *ENZYMES, *PATENTS, *PHOSPHOLIPIDS, SYNTHESIS, MOLECULES, HYDROXYL RADICALS, HALOGENS, ALCOHOLS

Subject Categories : Organic Chemistry
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE