Accession Number : ADD017956

Title :   An Internal Gelation Method for Forming Multilayer Microspheres and Product Thereof.

Descriptive Note : Patent Application, Filed 26 Dec 95,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Price, Ronald R ; Monshipouri, Mariam

PDF Url : ADD017956

Report Date : 26 Dec 1995

Pagination or Media Count : 39

Abstract : Microspheres, of controllable shape and size, encapsulating active ingredients, are made by the internally controlled gelation of an emulsion including a water-soluble polysaccharide, a salt of a di- or trivalent metal cation, a polymerization inhibitor, water, a water-immiscible solvent (as a non-aqueous phase), and the active ingredient. The components of the aqueous phase, containing the water-soluble polysaccharide, polymerization inhibitor, di- or trivalent metal salt, active substance, and water, are blended together. This aqueous phase is then gradually mixed with the oil phase and agitated to form an emulsion. After sufficient time for solidification, the emulsion is broken and the resulting microspheres are collected. The active ingredient may be various substances, including live microorganisms.

Descriptors :   *PATENT APPLICATIONS, *HYDROCARBONS, *CONTAMINANTS, *MEDICAL RESEARCH, *MICROORGANISMS, *GELATION, *MICROSPHERES, CONTROL, METALS, CATIONS, LAYERS, WATER, POLYSACCHARIDES, ENZYMES, POLYMERIZATION, SOLIDIFICATION, INTERNAL, CATALYSTS, VALENCE, SOIL POLLUTION, SALTS, INHIBITORS, MEDICAL SERVICES, OILS, WATER SOLUBLE MATERIALS, EMULSIONS, BIOLOGICAL PRODUCTS

Subject Categories : Microbiology
      Physical Chemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE