Accession Number : ADD018363

Title :   Antisense Oligonucleotides Directd against Human ICAM-I RNA.

Descriptive Note : Patent, Filed 12 Oct 93, patented 3 Dec 96,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Hoke, Glenn D ; Bradley, Matthews O ; Williams, Taffy J ; Lee, Che-Hung

Report Date : 03 Dec 1996

Pagination or Media Count : 16

Abstract : The present invention provides a method for the treatment of septic shock and inflammatory complications of shock. A process for selectively inhibiting the expression of the human ICAM-I mRNA transcript using at least one oligonucleotide which is complementary to at least a portion of the human ICAM-I mRNA is disclosed, as are oligonucleotides which are complementary to portions of the ICAM-I mRNA and compositions comprising the oligonucleotides.

Descriptors :   *OLIGOMERS, *SHOCK(PATHOLOGY), *PATENTS, *NUCLEOTIDES, POISONING, INFLAMMATION, RIBONUCLEIC ACIDS, MICROORGANISMS

Subject Categories : Biochemistry
      Medicine and Medical Research
      Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE