Accession Number : ADD018364

Title :   Antisense Oligonucleotides Directed against Human ELAM-I RNA.

Descriptive Note : Patent, Filed 12 Oct 93, patented 17 Dec 96,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Hoke, Glenn D ; Bradley, Matthews O ; Williams, Taffy J ; Lee, Che-Hung

Report Date : 17 Dec 1996

Pagination or Media Count : 16

Abstract : The present invention provides a method for the treatment of septic shock and inflammatory complications of shock. A process for selectively inhibiting the expression of the human ELAM-I mRNA transcript using at least one oligonucleotide which is substantially complementary to at least a portion of the ELAM-I gene is disclosed, as are composition comprising the oligonucleotide

Descriptors :   *INFLAMMATION, *OLIGOMERS, *SHOCK(PATHOLOGY), *RESPIRATORY DISEASES, *PATENTS, *NUCLEOTIDES, SIGNS AND SYMPTOMS, POISONING, RIBONUCLEIC ACIDS, MICROORGANISMS

Subject Categories : Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE