Accession Number : ADD018396

Title :   Antisense Oligonucleotides Directed Against Human VCAM-1 RNA.

Descriptive Note : Patent, Filed 12 Oct 93, patented 21 Jan 97,

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Hoke, Glenn D ; Bradley, Matthews O ; Williams, Taffy J ; Lee, Che-Hung

Report Date : 21 Jan 1997

Pagination or Media Count : 18

Abstract : Antisense oligonucleotides complementary to human mRNAs or pre-mRNAs coding for VCAM-1 are used in a therapeutic treatment of sepsis (sepsis, the sepsis syndrome, sepsis shock and all other manifestations of the sepsis disease, including but not inclusive of, adult respiratory distress syndrome, multi-organ failure, or cardiovascular dysfunction).

Descriptors :   *CARDIOVASCULAR SYSTEM, *RIBONUCLEIC ACIDS, *SHOCK(PATHOLOGY), *RESPIRATORY DISEASES, *PATENTS, *NUCLEOTIDES, HUMANS, DISEASES, SIGNS AND SYMPTOMS, THERAPY, DYSFUNCTION, SEPSIS

Subject Categories : Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE