Accession Number : ADD018397

Title :   Immunogenic Four Amino Acid Epitope against Plasmodium Vivax.

Descriptive Note : Patent, Filed 9 Mar 92, patented 4 Feb 97.

Corporate Author : DEPARTMENT OF THE NAVY WASHINGTON DC

Personal Author(s) : Hoffman, Stephen L ; Charoenvit, Yupin ; Jones, Trevor R

Report Date : 04 Feb 1997

Pagination or Media Count : 10

Abstract : An agent and pharmaceutical formulations of the agent containing a synthetic peptide of the human malaria Plasmodium vivax, containing at least one repeat of a synthetic peptide having the amino acid sequence Ala-Gly-Asp-Arg (AGDR) which is a protective epitope found on the circumsporozoite (CS) protein of the sporozoite of the human malaria Plasmodium vivax. When a monoclonal antibody specific for this four amino acid sequence hinds to the CS protein of the P. vivax sporozoite in vivo, infection is prevented.

Descriptors :   *PEPTIDES, *MALARIA, *SPOROZOITES, *AMINO ACIDS, *PATENTS, *PLASMODIUM VIVAX, HUMANS, PROTEINS, FORMULATIONS, SEQUENCES, INFECTIOUS DISEASES, DRUGS, IN VIVO ANALYSIS

Subject Categories : Biochemistry
      Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE