Accession Number : ADP001824

Title :   Effect of Dimethyl Sulfoxide on the Bactericidal Function of Polymorphonuclear Leukocytes,

Corporate Author : COLORADO UNIV HEALTH SCIENCES CENTER DENVER

Personal Author(s) : Repine,John E. ; Fox,Richard B. ; Berger,Elaine M.

Report Date : JUN 1983

Pagination or Media Count : 3

Abstract : Dimethyl sulfoxide (DMSO) is now being widely used to treat various rheumatic, musculoskeletal, and inflammatory conditions, but the therapeutic and detrimental consequences of treating individuals with DMSO remain unclear. We have examined the possibility that DMSO might inhibit the bactericidal function of polymorphonuclear leukocytes (PMN) by scavenging hydroxyl radical (.OH), one of the key bactericidal components of PMN. Our results suggest that DMSO can decrease the ability of PMN to kill Staphylococcus aureus in vitro and that this inhibition may occur because DMSO scavenges .OH. These observations suggest that DMSO might impair PMN-mediated host defense.

Descriptors :   *Methyl sulfoxide, Symposia, Polymorphonuclear leukocytes, Inhibition, Chemotherapy, Reduction, Hydroxyl radicals

Distribution Statement : APPROVED FOR PUBLIC RELEASE