Accession Number : ADP001826

Title :   Comparison of the Analgesic Effects of Dimethyl Sulfoxide and Morphine,

Corporate Author : EMORY UNIV ATLANTA GA SCHOOL OF MEDICINE

Personal Author(s) : Haigler,Henry J. ; Spring,Denise D.

Report Date : JUN 1983

Pagination or Media Count : 9

Abstract : DMSO produces analgesia in rats on tests that typically only detect the analgesic effects of potent narcotic analgesic drugs (i.e. the hot-plate and tail-flick tests). There seem to be two components of this analgesic effect; one component related to a local effect and the other component related to a systemic effect. If only the feet are exposed to DMSO, the rat becomes analgesic on the hot-plate and tail-flick. If a greater surface body is exposed, the rat becomes analgesic on both the hot plate and tail flick indicating a central action, because the tail did not come into contact with the DMSO. In one study on patients the authors conclude that the analgesic effect of DMSO arises from a central, not local, analgesic effect. The analgesic effects of DMSO are not consistently blocked by naloxone indicating that these analgesic effects of DMSO are not consistently blocked by naloxone indicating that these analgesic effects of DMSO do not have the same mechanism of action as morphine.

Descriptors :   *Methyl sulfoxide, *Morphine, Symposia, Analgesics, Physiological effects, Dosage, Rats

Distribution Statement : APPROVED FOR PUBLIC RELEASE