Accession Number : ADP001830

Title :   Ocular Toxicology of Dimethyl Sulfoxide and Effects on Retinitis Pigmentosa,

Corporate Author : TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON DEPT OF OPHTHALMOLOGY

Personal Author(s) : Garcia,Charles A.

Report Date : JUN 1983

Pagination or Media Count : 4

Abstract : Sixty-five patients were treated with DMSO, and fifty-eight served as controls. Data from patient follow-ups at one year, two years, and three years, and four to seven years after the last follow-up were compared. No objective, significant improvement was noted for visual acuity, color vision, visual fields, dark adaptation, electroretinography, or electrooculography in treated versus control groups. Over a two-year period, we did find minimal deterioration in visual acuity, but that observation in visual fields, color vision, and visual acuity in both the treated and non-treated groups. Because of our wide range of entering visual acuities, it is impossible to ascertain; in this population of patients whether or not a very subtle second-order effects are present with DMSO treatment. These finding contradict the earlier study that showed apparent improvement in vision or stabilization of vision in 48 of 50 patients.

Descriptors :   *Methyl sulfoxide, *Toxicology, Symposia, Retina, Vision, Visual acuity, Patients, Dark adaptation, Humans, Mice, Rodents, Physiological effects

Distribution Statement : APPROVED FOR PUBLIC RELEASE