Accession Number : ADP001831

Title :   Studies on Biological Actions of Dimethyl Sulfoxide in Familial Amyloidosis,


Personal Author(s) : Kito,Shozo ; Itoga,Eiko ; Inokawa,Masae ; Hironaka,Masatoshi ; Kishida,Takenobu

Report Date : JUN 1983

Pagination or Media Count : 15

Abstract : Dimethyl sulfoxide (DMSO) had not been regarded as a therapeutic drug against amyloidosis until 1974 when Osserman and Isobe administered it for the first time in six cases of primary amyloidosis. In 1973, we described an outline of the second largest concentration of familial amyloid polyneuropathy (FAP) cases which we discovered. We reported some tentative results of DMSO treatment in 18 cases. In this paper, we are presenting the effects of DMSO administration to patients with primary and familial amyloidosis from both clinical and biochemical viewpoints and in vitro effects of DMSO on extracted amyloid fibril proteins.

Descriptors :   *Methyl sulfoxide, Symposia, Chemotherapy, Patients, In vitro analysis

Distribution Statement : APPROVED FOR PUBLIC RELEASE