Accession Number : ADP001854

Title :   Treatment of Cerebral Infarction with Dimethyl Sulfoxide in the Mongolian Gerbil,

Corporate Author : LOUISVILLE UNIV KY SCHOOL OF MEDICINE

Personal Author(s) : McGraw,C. Patrick

Report Date : JUN 1983

Pagination or Media Count : 8

Abstract : Dimethyl sulfoxide (DMSO) has been reported to have beneficial effects in the treatment of central nervous system trauma, possibly due to its reported anti-inflammatory, antiedemic, anticoagulate, diuretic, hypothermic, vasodilatory, and respiratory stimulatory effects as well as an ability to correct membrane instability and penetrate the blood-brain barrier. In this paper we discussed these properties, and how they may be of benefit in ischemic cerebral infarction and elevated intracranial pressure. We also described a study we performed to determine if treatment with DMSO would decrease the morbidity and mortality from experimental cerebral infarction.

Descriptors :   *Methyl sulfoxide, Symposia, Brain, Infarction, Chemotherapy, Physiological effects, Trauma, Edema, Inflammation, Rhesus monkeys

Distribution Statement : APPROVED FOR PUBLIC RELEASE