Accession Number : ADP001856

Title :   Role of Dimethyl Sulfoxide in Prostaglandin-Thromboxane and Platelet Systems After Cerebral Ischemia,


Personal Author(s) : De La Torre,Jack C.

Report Date : JUN 1983

Pagination or Media Count : 16

Abstract : Direct and empirical evidence indicates that intravenous administration of DMSO can arrest or reverse cerebral and extracerebral ischemia following experimental or clinical injury. When the delivery of oxygen and nutrients to the tissue is deficient or unavailable (as in ischemia), cell damage or death with all its attending pathological consequences becomes an end-point. In the brain, this equates to a build-up of intracranial pressure, impairment of neural transmission to vital centers, and loss of function or death. We have reviewed a number of studies that show the usefulness of DMSO in preventing significant pathology from developing in various experimental injury models and in clinical subjects. We have proposed that the action of DMSO in biochemical, morphological, and functional subsystems is not specific but rather interactive. FIGURE 5 illustrates this point. Any one effect by DMSO on these subsystems that does not affect the others seems highly unlikely. How DMSO or similar drugs affect these systems, could provide important clues in clarifying the pathogenesis of ischemia and in reducing its severity. We conclude from the available evidence that ischemic injury is a dynamic process constantly promoting biochemical, vascular, and morphological changes and that DMSO is able to intervene at various levels of this pathochemical cascade.

Descriptors :   *Methyl sulfoxide, Symposia, Brain, Ischemia, Blood platelets, Prostaglandin, Pathology, Physiological effects

Distribution Statement : APPROVED FOR PUBLIC RELEASE