Accession Number : ADP001858

Title :   Dimethyl Sulfoxide Inhibition of Prostacyclin Production in Cultured Aortic Endothelial Cells,

Corporate Author : OREGON UNIV HEALTH SCIENCES CENTER PORTLAND DEPT OF ANATOMY

Personal Author(s) : Alam,Syed S. ; Layman,Don L.

Report Date : JUN 1983

Pagination or Media Count : 3

Abstract : Prostaglandin metabolism is significantly altered in advanced atherosclerosis, resulting in an increased platelet aggregation and adhesiveness. Inhibition of prostacyclin (PGI) biosynthesis by arterial endothelial cells and stimulation of thromboxane A by; platelets has been observed in experimentally induced atherosclerosis in; animals. Dimethyl sulfoxide (DMSO) has been reported to impair platelet aggregation and to inhibit PGE and PGF synthesis in seminal vesicle microsomes in vitro. Because of these reports we have investigated the effect of DMSO and its major metabolite, dimethyl sulfone on the synthesis of PGI by cultured endothelial cells.

Descriptors :   *Methyl sulfoxide, *Sulfones, Symposia, Inhibition, Endothelium, Cells(Biology), Production, Methyl radicals

Distribution Statement : APPROVED FOR PUBLIC RELEASE