Accession Number : ADP001863

Title :   Suppression of Atherosclerosis in Cholesterolemic Rabbits by Dimethyl Sulfoxide,

Corporate Author : OREGON UNIV HEALTH SCIENCES CENTER PORTLAND DEPT OF ANATOMY

Personal Author(s) : Layman,Don L. ; Alam,Syed S. ; Newcomb,Kenneth C.

Report Date : JUN 1983

Pagination or Media Count : 4

Abstract : The results of this study indicate that DMSO retards the development of dietary cholesterol-induced atherosclerosis in rabbits and suppresses the accumulation of cholesterol in tissues despite severe hypercholesterolemia. While the mechanism of action of DMSO in suppressing atheosclerosis is not known, our in vitro studies suggest that one of its antiatherogenic effects is related to its capacity to reduce the binding, uptake, and degradation of plasma LDL by tissues and cells.

Descriptors :   *Methyl sulfoxide, Symposia, Atherosclerosis, Reduction, Rabbits, Cholesterol, Inhibition

Distribution Statement : APPROVED FOR PUBLIC RELEASE