Accession Number : ADP001864

Title :   The Effect of Topical Dimethyl Sulfoxide on Clotting Activity in the Sprague-Dawley Rat,

Corporate Author : TEXAS TECH UNIV HEALTH SCIENCES CENTER LUBBOCK DEPT OF OBSTETRICS AND GYNECOLOGY

Personal Author(s) : Lox,Charles D. ; Frederick,Nora ; Heine,M. Wayne

Report Date : JUN 1983

Pagination or Media Count : 4

Abstract : In 1964 the first report describing the clinical use of dimethyl sulfoxide (DMSO) appeared, soon followed by similar clinical studies. Studies on toxicological effects of dimethyl sulfoxide soon appeared. But few evaluated potential hepatic toxicity. Dimethyl sulfoxide was reported to act as a possible carrier of hepatic carcinogens and cause an occasional increase in liver enzymes, and also acted as a very mild potentiator of hepatic lesions in the rat. As some of the clotting proteins are synthesized in the hepatic cell, this study was undertaken to see what, if any, changes in coagulation parameters might result following topical dimethyl sulfoxide treatment of the Sprague-Dawley rat. There was no significant alterations in body weight in either male or female Sprague-Dawley rats following one week of topical DMSO. Clotting time following treatment can be seen in TABLE 1.

Descriptors :   *Methyl sulfoxide, Symposia, Blood coagulation, Time, Rats, Body weight, Tables(Data)

Distribution Statement : APPROVED FOR PUBLIC RELEASE