Accession Number : ADP001865

Title :   The Effects of Chronic DMSO (Dimethyl Sulfoxide) Administration on the Spontaneous Development of Autoimmune Disease in NZB, BXSB, and MRL/LPR Strain Mice,

Corporate Author : OREGON UNIV HEALTH SCIENCES CENTER PORTLAND

Personal Author(s) : Morton,J. I. ; Siegel,B. V. ; Weaver,W. J. ; Bristol,T. ; Jacob,S. W.

Report Date : JUN 1983

Pagination or Media Count : 3

Abstract : In conclusion, chronic DMSO injections did not retard or accelerate the pathogenesis of autoimmune-lymphoproliferative disease in three genetically distinct mouse models of systemic lupus. This result is consistent with observations described in our accompanying study, which showed no effect of DMSO injections on primary IgM or secondary IgM plus IgG antibody plague-forming cell responses after sheep erythrocyte immunization. Nor was any change in natural killer cell activity observed. It remains possible that other doses, routes, or regimens of DMSO treatment might influence disease pathogenesis.

Descriptors :   *Methyl sulfoxide, Symposia, Immunity, Mice, Pathogenesis, Autoimmune diseases

Distribution Statement : APPROVED FOR PUBLIC RELEASE