Accession Number : ADP001866

Title :   Dimethyl Sulfoxide-A Safe Drug Solvent for in vitro Screening against Cestode Parasite,


Personal Author(s) : Ahmad,M. ; Nizami,Wajih A.

Report Date : JUN 1983

Pagination or Media Count : 5

Abstract : The selection of a suitable solvent for water-insoluble anthelminthic drugs is one of the major problems in the study of the mode of action of anthelminthic drugs. Generally a suitable solvent should have maximum solubility and least toxicity to the parasites and/or biological models. DMSO has been used as a drug solvent, particularly for benzimidazole derivatives, but the effect of DMSO on the metabolism of the parasites hitherto remains unstudied. Therefore, the present study was undertaken on a parasite model, Avitellina lahorea, and some aspects of the carbohydrate metabolism were studied in presence of DMSO, because mebendazole (a benzimidazole derivative) specifically affects the carbohydrate metabolism.

Descriptors :   *Methyl sulfoxide, Symposia, Organic solvents, In vitro analysis, Processing, Antiparasitic drugs, Parasites, Metabolism, Carbohydrates, Worms

Distribution Statement : APPROVED FOR PUBLIC RELEASE