Accession Number : ADP001868

Title :   Improvement in Somatosensory Evoked Response Amplitude and Neurologic Function Following DMSO (Dimethyl Sulfoxide) in a Cat Model of Chronic Spinal Cord Compression,

Corporate Author : FORT WORTH MEDICAL CENTER TX

Personal Author(s) : McCallum,J. E.

Report Date : JUN 1983

Pagination or Media Count : 4

Abstract : Beginning at approximately five minutes after administration of intravenous DMSO, the evoked response amplitude increased rapidly. This increase was most striking in the second five minutes after administration, by which time the amplitude of the early components had increased by an average of 175%. A slow increase continued over the next 35 minutes, at which time the response seemed to plateau at about 225% of the control value. When the animals were examined following intraperitoneal DMSO the next day, the results were mixed. All animals were unable to stand at this time. Three animals showed no improvement after DMSO. Three animals were able to stand but not walk. Two were able to ambulate unsteadily. The improvements in function lasted from five to six hours, following which the animals returned to their pre-DMSO state and were sacrificed.

Descriptors :   *Methyl sulfoxide, Symposia, Central nervous system, Compression, Spinal column, Cats, Amplitude, Response(Biology)

Distribution Statement : APPROVED FOR PUBLIC RELEASE