Accession Number : ADP001871

Title :   Dimethyl Sulfoxide and the Calcium Paradox,

Corporate Author : UNIVERSITY HOSPITAL UTRECHT (NETHERLANDS) DEPT OF CARDIOLOGY

Personal Author(s) : Ruigrok,T. J. C. ; Moes,D. de ; Slade,A. M. ; Nayler,W. G.

Report Date : JUN 1983

Pagination or Media Count : 3

Abstract : The results indicate that DMSO does not protect rat hearts against the effects of calcium-free perfusion that predispose the myocardium to the calcium paradox. The calcium-paradox damage is reduced, however, when DMSO is present during the reperfusion phase. The reduction of the calcium paradox damage may be affected by the hyperosmolarity of the DMSO-containing reperfusion medium, reduction by DMSO of the energy-dependent accumulation of calcium by mitochondria, which can lead to severe cell damage, and enhancement of the calcium-accumulating ability of the sarcoplasmic reticulum, resulting in a decreased supply of calcium to the mitochondria during the reperfusion phase.

Descriptors :   *Methyl sulfoxide, Symposia, Heart, Calcium, Damage, Physiological effects, Rats, Mitochondria

Distribution Statement : APPROVED FOR PUBLIC RELEASE