Accession Number : ADP001968

Title :   Application of Animal Models for Immediate and Delayed Pulmonary Hypersensitivity: Characteristics of Delayed Reactions to Tuberculin Protein,

Corporate Author : PITTSBURGH UNIV PA DEPT OF INDUSTRIAL ENVIRONMENTAL HEALTH SCIENCES

Personal Author(s) : Karol,Meryl H. ; Magreni,Cathleen ; Stadler,Judith

Report Date : AUG 1983

Pagination or Media Count : 8

Abstract : Delayed-onset pulmonary reactions have been reported following exposure to a wide variety of environmental and industrial allergens. Reactions are characterized by onset more than one hour after exposure. Frequently reactions occur from 4-24 hours following exposure. Pathogenesis of such reactions remains unclear. In the animal model described here, repeated inhalation challenge of guinea pigs with PPD aerosol resulted in a pattern of respiratory response different from that seen upon first bronchial provocation challenge. Second and third challenges elicited reactions with both earlier onset and earlier wane of response. This response pattern was produced consistently when animals were rechallenged with PPD antigen at 2-week intervals. However, by extending from 2 to 6 weeks the time between PPD challenges, the respiratory response to challenge resembled that seen upon first challenge. These experiments indicated that time between respiratory response affected onset of delayed pulmonary reactions.

Descriptors :   *Toxicology, *Pulmonary function, *Hypersensitivity, *Tuberculin, *Proteins, *Symposia, Immunology, Allergens, Exposure(Physiology), Injection, Reaction time, Delay, Pathogenesis, Allergic diseases, Aerosols, Inhalation, Bronchi, Response(Biology), Guinea pigs, Anatomical models

Distribution Statement : APPROVED FOR PUBLIC RELEASE