Accession Number : ADP001973

Title :   Comparisons of the Respiratory Functional Responses of Animals and Man,

Corporate Author : LOVELACE BIOMEDICAL AND ENVIRONMENTAL RESEARCH INST ALBUQUERQUE NM INHALATION TOXICOLOGY RESEARCH INST

Personal Author(s) : Mauderly,Joseph L. ; Silbaugh,S. A. ; Likens,S. A. ; Harkema,J. R. ; Johnson,W. K.

Report Date : AUG 1983

Pagination or Media Count : 24

Abstract : Respiratory function tests provide a strong link between experimental animals and man, because of the ability to perform physiologically similar measurements. Much is known about the relationships between measured functional abnormalities, subjective loss of function, clinical abnormalities and occupational disability of man. Since respiratory function can be similarly quantitated in experimental animals, respiratory function data from animals comprise a pathway of extrapolation in the prediction of health effects of inhaled toxic materials in man. The data collected to date indicate that, if similar structural changes are induced in the lungs of animals and man, similar physiologic abnormalities will result. The manifestations of the underlying structural changes, as expressed in altered respiratory function values, may differ slightly among species; however, functional responses to lung injury appear to be similar in animals and man if they are correctly interpreted.

Descriptors :   *TOXICOLOGY, *LUNG FUNCTION TESTS, *RESPIRATORY DISEASES, *SYMPOSIA, PULMONARY FUNCTION, LABORATORY ANIMALS, HUMANS, COMPARISON, RESPIRATION, INHALATION, TOXIC AGENTS, TOXICITY, LUNG, PREDICTIONS, WOUNDS AND INJURIES

Distribution Statement : APPROVED FOR PUBLIC RELEASE