Accession Number : ADP001974

Title :   Comparative Biochemical Responses to Inhaled Toxicants,

Corporate Author : CALIFORNIA UNIV DAVIS

Personal Author(s) : Last,Jerold A.

Report Date : AUG 1983

Pagination or Media Count : 7

Abstract : Two model systems are described for the study of effects of airborne toxicants on structural proteins of the lung: mucus glycoprotein synthesis by tissue slices from large airways and collagen synthesis by tissue minces prepared from lung parenchyma. The basic biochemical responses of mammalian lungs to inhaled substances seem to be universal; differences observed in such responses tend to be quantitative rather than qualitative. While potential species differences in the biochemical responses of lungs to inhaled toxic substances must always be considered, such species differences will usually be in the extent of response or reside in the detailed structure of the molecules involved, not in the response itself. Usually biochemical differences observed in response to toxic agents reflect underlying differences in the cellular content of the inflamed, acutely damaged lung, rather than necessarily reflecting changes in resident lung cells per se.

Descriptors :   *TOXICOLOGY, *BIOCHEMISTRY, *INHALATION, *TOXIC AGENTS, *LUNG, *SYMPOSIA, PROTEINS, GLYCOPROTEINS, MUCOUS MEMBRANES, COLLAGEN, BIOSYNTHESIS, TISSUES(BIOLOGY), TOXICITY, RESPONSE(BIOLOGY), INFLAMMATION, PULMONARY EDEMA, OZONE, DAMAGE

Distribution Statement : APPROVED FOR PUBLIC RELEASE