Accession Number : ADP001975

Title :   General Considerations for Developing Pulmonary Extrapolation Models,

Corporate Author : ENVIRONMENTAL PROTECTION AGENCY RESEARCH TRIANGLE PARK NC ENVIRONMENTAL TOXICOLOGY DIV

Personal Author(s) : Miller,Frederick J. ; Graham,Judith A. ; Overton,John H. , Jr

Report Date : AUG 1983

Pagination or Media Count : 31

Abstract : Environmental toxicologists are confronted with the formidable task of interpreting the results from epidemiological, human clinical, and animal studies on air pollutants and assessing their relevance and implications concerning pollutant levels to which man can be safely exposed. Usually, the fraction of the total available toxicologic data base represented by epidemiologic and human clinical studies is quite small compared to the data available from animal studies. This data imbalance stems from the nature and inherent limitations of epidemiological and human clinical studies. By contrast, animal experimentation provides the choice of a wide range of concentrations, exposure regimens, chemical agents, biological parameters, and animal species. Relating dose response results obtained in animal studies to the human experience is currently difficult. Many of the these considerations can be resolved through the development and use of pulmonary extrapolation models which account for species differences in dosimetry and tissue sensitivity to the pollutant and the selective improvement of the health effects data base.

Descriptors :   *Toxicology, *Lung, *Mathematical models, *Pollutants, *Symposia, Epidemiology, Clinical medicine, Medical research, Air pollution, Exposure(Physiology), Concentration(Chemistry), Safety, Humans, Data bases, Experimental data, Laboratory animals, Dosage, Pulmonary function, Lung function tests, Dosimetry, Toxicity, Anatomical models

Distribution Statement : APPROVED FOR PUBLIC RELEASE