Accession Number : ADP001976

Title :   The Cytosol Receptor for 2,3,7,8-Tetrachlorodibenzo-P-Dioxin: Mediator of Two Distinctive Pleiotropic Responses,

Corporate Author : WISCONSIN UNIV-MADISON MCARDLE LAB FOR CANCER RESEARCH

Personal Author(s) : Knutson,Joyce C. ; Poland,Alan

Report Date : AUG 1983

Pagination or Media Count : 12

Abstract : This report discusses two experimental systems as models for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) toxicity: a) the response of the epidermis in HRS/J mice and b) the keratinization of mouse teratoma cell line XB. Each system illustrates the two distinctive pleiotropic responses to the halogenated aromatic hydrocarbons controlled by the cytosol receptor: the one primarily concerned with the induction of drug metabolizing enzymes; the other, a more extensive response, involving differentiation. From these data, we suggest a model which may provide a general framework in which to consider the tissue specific and species specific toxicity of the halogenated aromatic hydrocarbons.

Descriptors :   *Toxicity, *Dioxins, *Anatomical models, *Symposia, Toxicology, Immunology, Epidermis, Response(Biology), Keratinization, Cells(Biology), Halogenated hydrocarbons, Aromatic hydrocarbons, Drugs, Metabolism, Enzymes

Distribution Statement : APPROVED FOR PUBLIC RELEASE