Accession Number : ADP001977

Title :   The Starvation-Like Syndrome and 2,3,7,8-Tetrachlorodibenzo-P-Dioxin: New Ideas on the Mode of Action at the Whole Animal Level,


Personal Author(s) : Seefeld,Mark D. ; Peterson,Richard E.

Report Date : AUG 1983

Pagination or Media Count : 13

Abstract : 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) and related compounds cause a starvation-like or wasting syndrome in several animal species. In young animals this response is manifested as a cessation of weight gain whereas in adults it is characterized by weight loss. The dose of TCDD required to elicit the response varies widely between species, as does the lethal dose (McConnell, 1980). However, if a dose of TCDD approaching the LD50 for a species is administered, a cessation of weight gain or a loss of weight is consistently observed. This progressive response occurs in laboratory animals (mouse, hamster, rat, guinea pig, rabbit, dog, monkey), farm animals (chicken, cow, horse), and wildlife (mink, guppy, rainbow trout, coho salmon, northern pike). The mechanisms by which TCDD causes weight loss is unknown. It is the purpose of this paper to discuss the role of altered food intake, oxygen consumption, and gastrointestinal absorption in the weight loss response. In addition, we will present evidence which suggests that TCDD-induced weight loss in the rat occurs secondary to a reduction in the animal's set-point for regulated body weight.

Descriptors :   *Toxicology, *Starvation, *Dioxins, *Symposia, Toxicity, Weight reduction, Body weight, Dosage, Lethal dosage, Food consumption, Oxygen consumption, Gastrointestinal system, Absorption, Rats

Distribution Statement : APPROVED FOR PUBLIC RELEASE