Accession Number : ADP001981

Title :   Inhalation Exposure Study of a Solvent Refined Coal Material,

Corporate Author : BATTELLE PACIFIC NORTHWEST LABS RICHLAND WASH BIOLOGY DEPT

Personal Author(s) : Springer,David L. ; Mahlum,D. D. ; Ragan,H. A.

Report Date : AUG 1983

Pagination or Media Count : 11

Abstract : Batelle-Northwest is engaged in evaluation of the toxicologic effects of solvent-refined coal (SRC) materials. Their approach has been to develop a broad base of toxicologic data built on a rigorous chemical characterization of individual components. Initially, several SRC materials were evaluated for mutagenic and mammalian cell transformation activity (Pelroy and Stewart, 1981). Materials that had biological activity in the in vitro assays were evaluated in whole-animal studies such as chronic skin painting in mice (renne et al., 1981) and the initiation promotion assay in mouse skin (Mahlum, 1982). In addition, other studies such as assays for teratogenic events (Springer et al., 1982) and dominant lethality were conducted. Since the high-boiling materials were active as skin carcinogens, these studies have been extended to include an inhalation exposure study. The material selected for this study was heavy distillate (HD), the 550 - 850 F fraction from the SRC-II process, obtained from the pilot plant at Ft. Lewis, WA.

Descriptors :   *Toxicology, *Inhalation, *Coal, *Symposia, Toxicity, Dosage, Exposure(Physiology), Solvents, Refining, Distillates, Heavy fuels, Weight reduction, Growth(Physiology), Survival(General), Tissues(Biology), Weight, Liver, Excretion, Rates, Thymus, Immunity, Blood cells, Leukocytes, Rats

Distribution Statement : APPROVED FOR PUBLIC RELEASE