Accession Number : ADP001982

Title :   Effect of Stoddard Solvent on Kidney Function and Structure of Fischer 344 and Sprague-Dawley Rats,

Corporate Author : EXXON CORP EAST MILLSTONE NJ RESEARCH AND ENVIRONMENTAL HEALTH DIV

Personal Author(s) : Phillips,Richard D.

Report Date : AUG 1983

Pagination or Media Count : 9

Abstract : Previous subchronic vapor inhalation studies with a number of light hydrocarbon materials have shown a pattern of kidney damage in male rats (Carpenter et al., 1975a, 1975b, 1975c, 1975d). The kidney damage involved the proximal portion of the tubule. The changes were described as regenerative tubular epithelium and dilated turbules containing proteinaceous material. Following analyses of these studies a number of questions were raised and a program was developed to address these questions. Part of that program consisted of an 8-week inhalation study with Stoddard Solvent. The major emphasis of this study was on the clinical assessment of renal function and its comparison to structural damage.

Descriptors :   *Toxicity, *Cleaning compounds, *Solvents, *Kidneys, *Symposia, Toxicology, Rats, Vapors, Inhalation, Exposure(Physiology), Dosage, Hydrocarbons, Kidney function tests, Damage, Kidney diseases, Pathology, Time intervals

Distribution Statement : APPROVED FOR PUBLIC RELEASE