Accession Number : ADP001985

Title :   Comparison of the Subchronic Inhalation Toxicity of Petroleum and Oil Shale Diesel Fuel Marine,


Personal Author(s) : Gaworski,Charles L. ; MacEwen,J. D. ; Leahy,H. F. ; Latendresse,J. R. ; Pitts,L. Loring

Report Date : AUG 1983

Pagination or Media Count : 13

Abstract : A standard protocol was developed to investigate the effects of low level long-term inhalation exposure to Petroleum and Oil Shale Fuels. Included in the design of the protocol was the capability to assess the effects immediately after exposure as well as monitor possible recovery or potential oncogenic activity. A continuous type of exposure was chosen. The principal sites of toxicity resulting from exposure to petroleum or shale DFM were the liver and kidney. Mild lung irritation seen in rats exposed to petroleum DFM and mice exposed to shale Diesel Fuel Marine (DFM) was similar in aspect to chronic respiratory disease. The lesion occurred frequently in the respective unexposed control groups and was probably reversible. Hepatocellular vacuolization is a nonspecific change which may indicate excess lipid accumulation. No detrimental liver tissue alterations were noted in male rats; however, increased liver weights in the high dose DFM exposed male rats may indicate a response to the need for additional metabolic capacity from this organ. By far the most striking and consistent effect noted after inhalation of DFM vapors was nephrotoxicity in male rats.

Descriptors :   *Toxicity, *Inhalation, *Petroleum products, *Oil shales, *Diesel fuels, *Symposia, Toxicology, Exposure(Physiology), Dosage, Low level, Long range(Time), Recovery, Neoplasms, Liver, Kidneys, Lung, Irritation, Lesions, Laboratory tests

Distribution Statement : APPROVED FOR PUBLIC RELEASE