Accession Number : ADP003865

Title :   Prevention of Ischemia-Induced Acute Renal Failure,

Corporate Author : COLORADO UNIV AT DENVER DEPT OF MEDICINE

Personal Author(s) : Schrier,R. W. ; Arnold,P. E. ; Burke,T. J.

Report Date : 29 APR 1983

Pagination or Media Count : 6

Abstract : Mannitol, furosemide, prostaglandin E2, and verapamil have been demonstrated to be protective against ischemic acute renal failure. Although the functional improvements in such renal parameters as glomerular filtration rate and tubular reabsorption of sodium are clearly demonstrable after therapy, the cellular mechanism(s) that underlie the decreased renal function are not well understood. These pharmacological agents exert multiple physiological effects, and it has been difficult to attribute their protective effect(s) to a common mechanism. However, new insights into the protective role of each of these drugs have been derived from our sequential studies of mitochondrial function during and following ischemia in both the intrarenal norepinephrine model (NE; 0.75 mg/kg/min) and the renal artery clamp model (45-50 min) of ischemic acute renal failure (ARF) in dog and rat, respectively.

Descriptors :   *Drugs, *Ischemia, Preventive medicine, Kidneys, Failure, Damage, Mitochondria, Dogs, Rats, Symposia

Distribution Statement : APPROVED FOR PUBLIC RELEASE