Accession Number : ADP004020

Title :   Molecular Mechanisms of n-Hexane Neurotoxicity,

Corporate Author : NEW YORK STATE DEPT OF HEALTH ALBANY

Personal Author(s) : DeCaprio,A. P.

Report Date : AUG 1984

Pagination or Media Count : 20

Abstract : A hypothetical molecular mechanism of action must ideally account for the structure/activity relationships, neurofilament accumulation, in vivo covalent protein binding, direct action on axonal components, and target organ specificity which are characteristic of the neuropathy caused by these compounds. Although this ideal has not yet been realized, substantial progress has been made toward elucidation of the crucial events leading to neuropathy. Ultimate success awaits exploration of the molecular interaction of the neurotoxic diketones with axonal components in vivo. The distinguishing features of n-hexane neuropathy are listed.

Descriptors :   *Toxicology, *Hexanes, Neurology, Ketones, Chemicals, Nerve fibers, Proteins, In vivo analysis, Symposia

Distribution Statement : APPROVED FOR PUBLIC RELEASE