Accession Number : ADP004020
Title : Molecular Mechanisms of n-Hexane Neurotoxicity,
Corporate Author : NEW YORK STATE DEPT OF HEALTH ALBANY
Personal Author(s) : DeCaprio,A. P.
Report Date : AUG 1984
Pagination or Media Count : 20
Abstract : A hypothetical molecular mechanism of action must ideally account for the structure/activity relationships, neurofilament accumulation, in vivo covalent protein binding, direct action on axonal components, and target organ specificity which are characteristic of the neuropathy caused by these compounds. Although this ideal has not yet been realized, substantial progress has been made toward elucidation of the crucial events leading to neuropathy. Ultimate success awaits exploration of the molecular interaction of the neurotoxic diketones with axonal components in vivo. The distinguishing features of n-hexane neuropathy are listed.
Descriptors : *Toxicology, *Hexanes, Neurology, Ketones, Chemicals, Nerve fibers, Proteins, In vivo analysis, Symposia
Distribution Statement : APPROVED FOR PUBLIC RELEASE