Accession Number : ADP004021

Title :   Pathology and Axonal Transport in Hexacarbon Neuropathies,

Corporate Author : OHIO STATE UNIV COLUMBUS COLL OF MEDICINE

Personal Author(s) : Sahenk,Z. ; Mendell,J. R.

Report Date : AUG 1984

Pagination or Media Count : 8

Abstract : These studies lead us to propose the following hypothesis. The earliest change in the axon following hexacarbon exposure is an alteration in the cytoskeleton, resulting in clusters of microtubule channels segregated from neurofilaments. Initially, fast anterograde transport continues through these functioning channels. With continued exposure, the cytoskeleton becomes chaotic, and pathways for moving organelles are impaired, affecting both anterograde and retrograde transport. The severe disruption in axoplasmic transport seems to play a key role in axonal degeneration, at least in part related to the failure of delivery of important materials to the distal axon. Furthermore, the accumulation of lysosomal material, carried by retrograde transport, may play a role in the initiation and/or acceleration of the intraaxonal digestive process which is part of nerve fiber degeneration.

Descriptors :   *Toxicology, *Organic compounds, Neurology, Pathology, Nerves, Nerve fibers, Transport properties, Morphology(Biology), Symposia

Distribution Statement : APPROVED FOR PUBLIC RELEASE