Accession Number : ADP004025

Title :   Electrophysiologic Changes in Organophosphorus-Induced Delayed Neurotoxicity,

Corporate Author : WARNER-LAMBERT/PARKE-DAVIS ANN ARBOR MI

Personal Author(s) : Anderson,R. J.

Report Date : AUG 1984

Pagination or Media Count : 9

Abstract : There is now a considerable body of literature showing that organophosphorus (OP) agents which produce organophosphorus-induced delayed neuropathy (OPIDN) also inhibit neurotoxic esterase (NTE). Although the functional relationship of these two events has not been established, the correlation is strong enough that NTE inhibition can be used as a reliable predictor of the peripheral neuropathy potency of a given agent (Johnson, 1975). There is a wealth of data describing the histopathology and biochemistry associated with OPIDN, but few electrophysiologic correlates have been made.

Descriptors :   *Toxicology, *Organic phosphorus compounds, Neurology, Electrophysiology, Inhibition, Nerves, Rats, Dosage, Symposia

Distribution Statement : APPROVED FOR PUBLIC RELEASE