Accession Number : ADP004032

Title :   Pharmacokinetic Interactions of Mixtures,

Corporate Author : AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH

Personal Author(s) : Andersen,M. E. ; Clewell,H. J. , III

Report Date : AUG 1984

Pagination or Media Count : 13

Abstract : This paper is divided into two sections. First, we describe several examples from the literature which indicate toxicologic or pharmacokinetic interactions arising during co-exposure to two vapors. Secondly, we discuss the metabolic basis of these interactions and try to generalize these results to illuminate the interactions that are expected during exposure to more complex mixtures. When possible, the examples in the second portion are given a quantitative basis by applying a physiological pharmacokinetic model to describe these interactions.

Descriptors :   *Toxicology, *Pharmacokinetics, *Hydrocarbons, *Vapors, *Hexanes, Mixtures, Interactions, Blood analysis, Metabolites, Physiological effects, Rats, Enzymes, Symposia

Distribution Statement : APPROVED FOR PUBLIC RELEASE