Accession Number : ADP004406

Title :   Effect of Injury or Resuscitation on Coagulation Mechanisms,

Corporate Author : UNIVERSITY OF SOUTH ALABAMA MOBILE COLL OF MEDICINE

Personal Author(s) : Curreri,P. W. ; Granger,N. ; Manwaring,D.

Report Date : 21 JAN 1983

Pagination or Media Count : 4

Abstract : In order to determine if products of fibrinolysis alter filtration or permeability, exogenous (purified Fragments D and E) products, and plasmin were tested in an isolated, autoperfused catileum preparation. Steady-state lymphatic and plasma protein concentration ratio (C sub L/C sub P) and lymph flows (Q sub L) were measured at a venous outflow pressure of 0 mmHg. Data was analyzed for each animal group by the paired Student test for Q sub L, C sub L/C sub P, and protein clearance (Q sub L x C sub L/C sub P). In cats which received Fragment D (n=7), Q sub L and clearance increased five-fold (P < 0.002), but C sub L/C sub P) was not altered, which suggests a permeability change. Ileal mucosa wa depithelialized and blood vessels were damaged. Fragment E (n=7) provoked a slight increase in Q sub L (P<0.01), but not in C sub L/P E sub L or clearance. Histology was normal.

Descriptors :   *BLOOD COAGULATION, *FIBRINOLYSIS, *BURNS(INJURIES), FIBRINOGEN, CATS, LABORATORY ANIMALS, FILTRATION, PERMEABILITY, SYMPOSIA

Distribution Statement : APPROVED FOR PUBLIC RELEASE