Accession Number : ADP004410

Title :   Subeschar Antibiotic Infusion in the Treatment of Burn Wound Infection,

Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX

Personal Author(s) : McManus,W. F.

Report Date : 21 JAN 1983

Pagination or Media Count : 4

Abstract : Five of 19 patients survived after histologic confirmation of burn wound infection. Five additional patients had no evidence of residual burn wound infection at death. Thus, 10 of 19 patients, 52.6% had effective treatment of burn wound infection. Nine patients, 47.4% died with burn wound infection despite treatment. Nine of 593 patients in a two-year period prior to the use of subeschar antibiotic infusion required emergency excision of infected burn wounds in an attempt to control bacterial burn wound sepsis. The use of subeschar antibiotics has eliminated the necessity for emergency excision of infected burn wounds in this Center and has permitted elective operation on patients who have had adequate preoperative antibiotics and supportive therapy thus minimizing the risk of intra or post operative septic shock. Subeschar antibiotic clysis using a semi-synthetic penicillin such as carbenicillin is an effective adjunct in the treatment of pseudomonas burn wound infection. Successful treatment depends on early histologic diagnosis, control of burn wound and disseminated infection, and definitive wound closure. (Author)

Descriptors :   *BURNS(INJURIES), *SURVIVAL(PERSONNEL), DIAGNOSIS(MEDICINE), ANTIBODIES, INFUSIONS, SYMPOSIA

Distribution Statement : APPROVED FOR PUBLIC RELEASE